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Simple timing framework Baseline Discuss baseline review before starting, especially with sleep disorders, psychiatric history, sedating medications, liver disease, or kidney disease

When a conclusive connection is shown between biomarkers and the preclinical stage, and when epidemiological studies include biomarkerbased diagnoses, it will be possible to estimate the number of individuals throughout the entire continuum of Alzheimer's disease (i.e., those with biomarkerconfirmed Alzheimer's dementia, those with biomarkerconfirmed MCI due to Alzheimer's disease and those with biomarkerconfirmed preclinical Alzheimer's disease)